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The 8-in-1 BioSerum is DefenAge's iconic bestseller. This patented technology, remarkably smart bio serum formula seems to understand your skin’s needs better than your DNA. Designed to activate, orchestrate, and energize the skin, this biologically advanced, anti-aging, and cream-like serum concentrate provides an unprecedented concentration of defensin molecules contained in the Age-Repair Defensin® Complex. Dermatologists and aesthetic professionals name defensins as a perfect retinol alternative and the 8-in-1 BioSerum as a retinol or bakuchiol serum replacement. The best part? Results are equal to eight separate serums. Get your best skin ever with 8-in-1 BioSerum.
The 8-in-1 BioSerum is perfect as a stand alone skincare product. The 8-in-1 BioSerum is also well known as a "treatment multiplier," dermatologists recommend the 8-in-1 BioSerum for pre- and post- aesthetic procedures to amplify the results of microneedling, RF-microneedling, fractional and ablative laser, and Sofwave. Find more about expected results when you add the 8-in-1 BioSerum to your treatment at the Clinical Studies tab.
Read expert opinions here.
How Our Bio Serum Works
The DefenAge 8-in-1 BioSerum works by improving the overall health and appearance of the skin. It helps
• Rejuvenates smoothness. Improves overall visible skin health and quality.
• Minimizes the look of fine lines, wrinkles, pores, and skin pigmentation and discolorations.
• Promotes radiance and revives the skin’s natural moisture for an ultimate glow.
• Brightens the overall skin tone and clarity and enhances skin luminosity.
• Renews the feeling of skin firmness, elasticity, and texture.
• Helps improve the appearance of skin redness.
• Promotes the skin barrier and skin immunity.
Why 8-in-1 BioSerum Is Different
Our bio serum is an excellent retinol and bakuchiol serum alternative. We’ve combined advanced, targeted treatment with established and validated science to bring you a skin care product that is unlike any other on the market. Here’s what makes 8-in-1 BioSerum different.
• Contains five times more defensin molecules than any other formula.
• Light-weight application; “you don't feel it when you're wearing it”.
• Effective and safe for the entire face, including the delicate skin around the eyes and lips, and the neck and décolleté.
• High-performing on crepey thin skin on the neck and arms.
• Fast-acting anti-aging — first results are seen within a few weeks.
• Perfect as a daily skin care product for both men and women.
• Effective for all stages of skin aging, including for people above 70.
• Non-irritating and gentle on sensitive skin, unlike retinol.
• Tolerated by all skin types, including those with rosacea and melasma.
• Highly effective for pre- and post- aesthetic procedures to achieve the optimal outcomes, including microneedling and fractional and resurfacing laser treatments. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.
• Effective in preparing skin before fillers — start using four to six weeks before procedures.
• DefenAge's most “likable” product with the most impressive consumer feedback.
Made in the U.S.A.
Add These Moisturizers to Your BioSerum Routine:
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Ten Specific Ways Leading Dermatologists Recommend Using the 8-in-1 BioSerum:
For daily use. It’s lightweight. “You can’t even feel it when you’re wearing it.” Dermatologist Vivian Bucay, MD
For sensitive skin. It delivers anti-aging results but it’s “not irritating like a retinol or acids.” Dermatologist Anne Chapas, MD
For older age. Even old skin has young dormant cells that can be turned on by defensins. “We saw a marked difference at 2 months” in a 73-year-old patient. Dermatologist Angela Bowers, MD
For better skin quality, including firmer skin, fewer fine lines, more luminosity and clarity, and a reduced appearance of pores. Dermatologist Anne Chapas, MD
After microneedling, patients are “less likely to break out with acne post treatment.” Dermatologist Vivian Bucay, MD
“4 to 6 weeks before having filler procedures” to prep the skin and enhance results. Dermatologist Kathleen Welsh, MD
Before and after ablative skin treatments, which “primes skin to respond more quickly and robustly, healing faster.” Dermatologist Steven Swengel, MD
To target specific areas, including around the eyes and lips. Dermatologist Angela Bowers, MD
Beyond the face: on the neck and décolleté. Dermatologist Steven Swengel, MD
For crepey thin skin on the neck and arms. Dermatologist Kathleen Welsh, MD
REFERENCE:Dermatologists weigh in on DefenAge’s 8-in-1 BioSerum: Patient outcomes, optimal use. The Dermatology Digest (2021) January, p. 40-42.
How and Why You Should Add the 8-in-1 BioSerum to Your Skincare Regimen?
Dermatologists agree, if you do one nice thing for your skin this year - introduce it to defensin-molecules. Defensins can be incorporated into your existing skincare regimen and do not conflict or compete with other skincare. Whether it’s CHANEL or Clinique, incorporating DefenAge + Defensins can actually enhance the skincare you already know and love.
Consumer survey says that 93% of consumers who use CHANEL
skincare also like the results they see with DefenAge!
/ Survey 2019, data on file /
“Why do CHANEL users like DefenAge? – this is simple – DefenAge’s defensins multiply the effect of other skincare. …Ironically, DefenAge skin care has no competition on the skincare market because it enhances any other skin care brands. Much like laser treatments and microneedling, the topical application of defensins causes our body to message ‘preserved,’ healthy cells to create visibly new skin. I recommend the BioSerum to my patients to activate their “skin’s memory”, triggering skin to look younger, twice a day – in the morning and evening by applying just one drop of DefenAge BioSerum over the moisturizer of their choice,”
-Board-certified dermatologist Natalie M. Curcio, M.D., M.P.H.
Check with us, what other skincare than CHANEL can be combined with DefenAge's defensins for more glowing skin.
Opinions and Stories
Healthy, Simple, and Safe Skincare Routines with Defensins from Supermodel Veronica Webb
by Veronica Webb, supermodel mom and influencer
Aging powerfully is as much about your attitude as it is about the skincare products you use. Veronica Webb, supermodel, mom, influencer, and beauty writer talks dermatologist recommended anti-aging clean beauty serums, moisturizers, and cleansers. Veronica shares her take simple safe and healthy confidence-boosting skincare routines that make a daily difference. Read more ...
How Effective Is Combining Products From Different Skincare Lines?
by Eliza Cabana, aesthetic and skin rejuvenation guru
Don’t want to give up your Chanel (or other) skincare product for something new? With DefenAge, you don’t have to! One expert explains how you can combine your favorite products with the DefenAge line to get all the benefits of both. Read more ...
The Secret to Effective 'Anti-Aging'
by Eliza Cabana, aesthetic and skin rejuvenation guru
Who doesn’t love a good anti-aging cream? But will it actually turn back the clock for your skin? One expert shares her perspective on the “anti-aging” misnomer as well as tips for what steps you can take to get the most out of your skincare routine. Read more...
Introduce Your Skin to the Benefits of DefenAge’s 8-in-1 BioSerum This Year
DefenAge’s 8-in-1 BioSerum may be lightweight, but it packs more Defensin molecules than any of DefenAge’s other products. Age-Repair Defensins wake up dormant cells to make brand-new, healthy cells. The result is skin that looks brighter, smoother, and firmer. If you don’t want to use retinol, try the dermatologist recommended skin care from DefenAge, including 8-in-1 BioSerum. Age-Repair Defensins are just as effective as retinol. Read more...
How to Get the Best Results From Your Anti-Aging Skin Care Products
The best anti aging skin care products will help your skin look brighter, smoother, plumper, and reduce the appearance of wrinkles. But if you want to truly maximize the product’s effectiveness, there are several things to keep in mind. Using skin care products that address signs of aging is a commitment, but it’s worth it when you start seeing results. Read more...
DefenAge’s Anti-Aging Serum: A Spring Skin Care Must-Have
The 8-in-1 BioSerum, anti-aging serum, from DefenAge is a best-selling product with the highest concentration of Age-Repair Defensins. Defensins are molecules that prompt dormant cells to make brand-new, healthy skin cells. DefenAge is the only brand to use Age-Repair Defensins, a proprietary ingredient. The result is new skin cells that look younger and healthier. DefenAge’s products don’t merely cover signs of visible aging.
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