This premium French maritime pine bark extract contains numerous bioactive compounds that support capillary and connective tissue function and provide antioxidant protection.  Pycnogenol® is a powerful scavenger of free radicals involved in inflammatory processes and supports elasticity and integrity of collagen in joints, capillaries, blood vessels, and skin. Pycnogenol® is one of the most powerful natural free-radical scavengers and it reduces oxidative damage to vital tissues in the body. In fact, it is one of the few antioxidants that is able to cross the blood barrier of the brain to provide extra protection against free radicals in the nervous system and circulatory system. Because vitamins C and E’s effectiveness are enhanced by Pycnogenol®, they can all be taken together for added antioxidant benefit. A 2006 study, published in the June 17 edition of The Journal of European Child and Adolescent Psychiatry, shows a significant reduction of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in children after supplementing with Pycnogenol every day for one month. In the randomized, double-blind placebo-controlled study, Pycnogenol helped reduce hyperactivity and improve attention, concentration and motor-visual coordination, compared with placebo.