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Clinical data
Pronunciation
/sɪlˈdɛnəfɪl/ sil-DEN-ə-fil
AHFS/Drugs.com
Monograph
MedlinePlus
a699015
License data
EU EMA: by INN
US DailyMed: Sildenafil
Pregnancycategory
AU: B1[1]
Routes ofadministration
Oral (tablets), intravenous, sublingual
ATC code
G04BE03 (WHO)
Pharmacokinetic data
Bioavailability
41% (mean)[7]
Protein binding
~96%
Metabolism
Liver: CYP3A4 (major route), CYP2C9 (minor route)
Metabolites
N-desmethylsildenafil (~50% potency for PDE5)
Onset of action
20 minutes
Elimination half-life
3–4 hours
Excretion
Feces (~80%), urine (~13%)[4]
Identifiers
CAS Number
139755-83-2 7
citrate: 171599-83-0
PubChem CID
135398744
citrate: 135413523
DrugBank
DB00203
citrate: DBSALT000347
ChemSpider
5023
citrate: 56586
UNII
3M7OB98Y7H
citrate: BW9B0ZE037
KEGG
D08514
citrate: D02229
ChEBI
CHEBI:9139
citrate: CHEBI:58987
ChEMBL
ChEMBL192
citrate: ChEMBL1737
PDB ligand
VIA (PDBe, RCSB PDB)
CompTox Dashboard (EPA)
DTXSID6023579
ECHA InfoCard
100.122.676
Chemical and physical data
Formula
C22H30N6O4S
Molar mass
474.58 g·mol−1
3D model (JSmol)
Interactive image
**The information provided is intended solely for educational purposes and should not be considered a replacement for professional medical advice. Additionally, it is important to note that research chemicals are intended solely for laboratory study by professional researchers and are not intended for human consumption.**
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