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Renue Blue Face & Hand Serum
Renue Blue Face & Hand Serum works at the cellular level to deliver time released actives that restore NAD⁺ to improve skin's texture, firmness, and dermal matrix.
The epitome of science and performance, Renue Blue Face & Hand Serum works renews cells from within using a proprietary Liposomal Methylene Blue with NAD⁺ Complex (NAD+, NMN, and NR)—science-backed nutrients that provide nourishment on the cellular level.
Renue Blue works at the cellular level to deliver time-released actives that restore NAD⁺ to improve skin's texture, firmness, and dermal matrix.
Nano-sized liposomes penetrate quickly and deeply into dermal layers to deliver a very high concentration of active ingredients that provide unique therapeutic benefits over all other serums.
Expertly formulated with liposomal NAD⁺ Complex (NAD+, NMN, and NR) and Methylene Blue, along with Apocynin, and Glutathione, this potent delivery system offers a deeper penetration of key ingredients into the skin's surface to combat the most visible signs of aging and promote vibrant, youthful-looking skin.
Use day and night with Renue Blue Face Creme. Suitable for all skin types.
METHYLENE BLUE
Methylene Blue has been studied for a wide range of ailments, many of which are aging-related illnesses, and there are currently over 20,000 studies on Pubmed. One study conducted at the University of Maryland tested the potential dermal anti-aging benefits of four antioxidants, one of which was Methylene Blue.
Among all of the antioxidants studied, Methylene Blue was by far, the most effective.
University of Maryland Study
Study Details
Progeria
Oxidative Stress Test
Skin cell proliferation
Senescence results
Dermal Thickness Results
Summary of Results
Sources
The study was conducted by the Department of Cell Biology & Molecular Genetics, at the University of Maryland.
In the study, researchers tested out four antioxidants on the skin, one of which was Methylene Blue. The second one was N. Acetyl Cysteine, or NAC, a very popular antioxidant, often taken as a supplement. The last two were MitoQ and mTEM - both of which are mitochondrial targeting antioxidants.
They applied each one topically to skin fibroblasts of healthy middle-aged adults, adults 80 and older and from people with progeria.
For most studies, skin fibroblasts are obtained through a non-invasive procedure that involves numbing at the site and taking a punch skin biopsy sample.
Progeria is an extremely rare genetic condition characterized by dramatic and rapid aging. It causes severe hardening of the arteries at a young age, and often those afflicted don't live past their teenage years.
Some researchers believe that Progeria may hold the key to understanding the precise causes of aging - so that it can be slowed down.
For this study, the Progeria fibroblasts were used as an accelerated model for normal aging - because they share many of the features in common with normal aging.
One part of the study looked at the effectiveness of these antioxidants to decrease oxidative stress. Oxidative stress plays a major role in the aging process in the skin, much of which is driven by UV exposure.
Among all of the antioxidants studied, Methylene Blue was the most effective.
It reduced mitochondrial reactive oxygen species, and promoted skin cell proliferation - which involves an increase in the cell division rate and that leads to a higher number of new, healthy cells created during cell turn-over.
The normal skin and the progeria skin treated with the Methylene Blue, showed much higher skin proliferation levels.
Research shows that as a person ages, proliferation of cells in the basal (or deepest) layer reduces. The epidermis (or the outer layer) then becomes thinner. The nutrition supply to the outer layer then weakens because of dysfunction in the deeper layers.
This process of decreased proliferation in the skin, is associated with senescence. Senescent cells, also known as zombie cells, can cause a lot of damage. They are cells that eventually stop multiplying, yet they don't die off like they should. Instead, they remain in the body and continue to release damaging chemicals that trigger inflammation.
In the second part of the study, cellular senescence was examined.
Different fibroblasts were used and treated with Methylene Blue. Two fibroblasts from people over 80 were used and two fibroblasts from people under 30 were used.
The over 80 fibroblasts showed increases in biomarkers of senescence. When treated with Methylene Blue, there was a reduction in cellular senescence, especially notable for the older skin fibroblasts. This showed that Methylene Blue is effective at reducing cellular senescence.
The study revealed that skin treated with Methylene Blue had an increase in skin thickness and improved levels of skin hydration.
This is important because skin thickness and loss of hydration are issues of aging skin. Dermal thickness decreases by about 6% every decade.
Source: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
Among all of the antioxidants studied, Methylene Blue was the most effective.
The Methylene Blue-treated skin showed a greater reduction in DNA damage, leading to cell rejuvenation.
There was an increase the cell division rate, leading to a higher number of healthy new cells created during cellular turnover.
In addition, there was less senescence - and a slower rate of cell death, indicating that skin cells became healthier and lived longer.
There was also improved hydration levels and dermal thickness was increased.
Study: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity https://www.nature.com/articles/s41598-017-02419-3
Fighting against Skin Aging The Way from Bench to Bedside https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047276/
The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging https://sci-hub.do/10.1016/j.dnarep.2014.04.005
NAD in Skin: Therapeutic Approaches for Niacin https://sci-hub.do/10.2174/138161209787185760
Characteristics of the Aging Skin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/
Xiong, ZM, O’Donovan, M., Sun, L., et al. Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Sci Rep 7, 2475 (2017) (https://doi.org/10.1038/s41598-017-02419-3). Licensed under CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Disclaimer – Neither the license nor link to the foregoing publication constitutes or implies any sponsorship or affiliation with, or endorsement or approval of Renue By Science by the authors.
RENUE™ - 2 Step Skin Rejuvenation Protocol
RENUE SERUM IS QUICKLY ABSORBED
Serums are made of very small molecules that penetrate your skin faster and more effectively, carrying the active ingredients to deeper layers and into systemic circulation.
Step 1: Apply face or body serum for penetration to deepest skin layers and systemic circulation.
Allow to soak in for 1-2 minutes
RENUE LOTION PROTECTS SURFACE LAYER
The thicker, more emollient ingredients in our Lotion and Face Creme concentrate more active ingredients in the surface layer.
Step 2: Apply Renue Face Creme, Lotion, or your favorite moisturizer
*note - Renue body lotion can be used alone, as the liposomes will also reach deep layers and systemic circulation, but in lesser quantities than serums. It is more effective to apply the serum first, then the lotion.
What's the ideal pH for skin-care products?
You want to look for skin-care products with a pH of 5.5. If anything, they could be as low as 4.5 and as high as 7. The general rule is slightly acidic is preferred for the best complexion.
What pH are Renue™ Products?
Renue™ NAD+ Skincare products are on the optimal 5.5 mark on the pH scale.
High pH (8 to 14)
Skin-care products with a high pH level (also known as alkaline) pose the biggest threat to your skin's pH and acid mantle. That tight, squeaky-clean feeling you might experience after washing your face is the truest sign of cleansers with a high pH and damaged skin barrier. They, as well as other alkaline skin-care products, tend to strip away sebum and natural oils.
Low pH (1 to 6)
Because products with a low pH are at a level closer to skin's natural pH, they will more effectively work with your skin and help cell turnover gently. They're more likely to keep skin bright and smooth, instead of flaky and angry.
However, certain products can be too low of a pH for skin and irritate it. At-home peels and other acid-spiked products tend to have a lower pH level, making them great exfoliants but just as stripping as products with a high pH.
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
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