Simparica Trio is a chewable tablet for dogs that provides broad-spectrum protection against fleas, ticks, heartworms, roundworms, hookworms, and whipworms. It contains three active ingredients - sarolaner, moxidectin, and pyrantel - that work together to protect your dog against these parasites. This chewable tablet is easy to administer orally, making it convenient for pet owners. Simparica Trio is a monthly treatment that provides protection for a full month with just one tablet. Please note that Simparica Trio is available only with a prescription from a licensed veterinarian, ensuring that it is used safely and effectively. Simparica Trio comes in a chewable tablet form, making it convenient to administer to dogs. The medication is typically prescribed by a veterinarian and is administered once a month for ongoing parasite protection. It's important to note that Simparica Trio is specifically designed for dogs and should not be used on other animals or humans. Additionally, it's always recommended to consult with a veterinarian before starting any new medication to ensure it is appropriate for your dog and to determine the correct dosage based on your dog's size and health condition. Key Features: Broad-Spectrum Protection: Protects against fleas, ticks, heartworms, roundworms, hookworms, and whipworms. Chewable Tablet: Easy to administer orally, making it convenient for pet owners. Monthly Treatment: Provides protection for a full month with one tablet. Suitable for Dogs: Formulated specifically for use in dogs. Prescription Only: Available only with a prescription from a licensed veterinarian. Indications: Simparica Trio is indicated for the prevention and treatment of several parasitic infections in dogs. Here are the main indications for using Simparica Trio: Fleas: Simparica Trio kills fleas (Ctenocephalides felis) and provides at least one month of protection against flea infestations. Ticks: Simparica Trio kills four common species of ticks that infest dogs: the black-legged tick (Ixodes scapularis), the American dog tick (Dermacentor variabilis), the Gulf Coast tick (Amblyomma maculatum), and the lone star tick (Amblyomma americanum). It provides at least one month of protection against ticks. Heartworm disease: Simparica Trio is effective in preventing heartworm disease (Dirofilaria immitis) by eliminating the infective larvae transmitted by mosquitoes. It should be administered monthly to ensure continuous protection against heartworm infection. Intestinal worms: Simparica Trio controls and treats intestinal worm infections in dogs. It is effective against roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), and whipworms (Trichuris vulpis). It helps to eliminate and prevent these parasites from establishing in the dog's intestines. It's important to note that Simparica Trio is intended for use in dogs only and is available in different strengths based on the weight of the dog. It should be administered as directed by a veterinarian, and the dosing schedule should be followed consistently for optimal effectiveness. How it works: Simparica Trio works through the combined action of its three active ingredients: sarolaner, moxidectin, and pyrantel. Let's look at how each ingredient works: Sarolaner: Sarolaner is an ectoparasiticide, which means it targets external parasites like fleas and ticks. When a dog ingests Simparica Trio, sarolaner is absorbed into the bloodstream. It then circulates throughout the dog's body. Sarolaner targets the nervous system of fleas and ticks, specifically by binding to receptors called gamma-aminobutyric acid (GABA) and glutamate receptors in these parasites. This binding disrupts the normal functioning of the parasites' nervous system, leading to paralysis and subsequent death of the fleas and ticks. Moxidectin: Moxidectin is an anthelmintic agent that is primarily effective against heartworms, but it also has activity against certain intestinal worms. Once absorbed into the bloodstream, moxidectin is distributed throughout the dog's body. It works by binding to specific receptors called glutamate-gated chloride channels in the nervous system of parasites. This binding causes an influx of chloride ions, leading to hyperpolarization and paralysis of the parasites. Moxidectin kills and prevents the development of heartworm larvae and provides control against certain species of roundworms and hookworms. Pyrantel: Pyrantel is an anthelmintic agent that primarily targets intestinal worms. After being ingested, pyrantel is poorly absorbed from the dog's gastrointestinal tract, and it remains primarily in the intestinal lumen. Pyrantel works by blocking the parasites' neuromuscular junction, specifically by causing depolarization and paralysis of the worms. This effect makes the worms lose their grip on the intestinal wall, allowing them to be expelled from the dog's system through normal bowel movements. By combining these three active ingredients, Simparica Trio provides a comprehensive approach to parasite control in dogs. It acts against fleas, ticks, heartworms, and common intestinal worms, offering a broad spectrum of protection. Regular monthly administration of Simparica Trio helps ensure continuous coverage and reduces the risk of parasite infestations and associated diseases in dogs. Specifications: Brand: Simparica Trio Active Ingredients: Sarolaner, moxidectin, pyrantel Type: Chewable Tablet Indicated For: Flea, tick, heartworm, roundworm, and hookworm prevention in dogs Dosage Form: Chewable tablet Strength: Various strengths available