Veterinarians may prescribe Silver Sulfadiazine Cream to help treat and prevent serious infections, such as Staph and E. coli, or to help severe burns and other wounds heal. It also offers itch relief to help keep your pet comfortable. Suitable for both cats and dogs, Silver Sulfadiazine Cream is an effective treatment that's antimicrobial in nature. When applying the cream, be sure to put enough to completely cover the wound and always follow your veterinarian's instructions. Rx only Antibiotic cream safe for cats and dogs Helps treat and prevent serious infections, such as Staph and E. coli Can also be applied to second- and third-degree burns in order to help prevent wound infection Provides relief from itchiness often associated with the healing process Approved for catheter-related infection prevention as well Thick cream is applied topically to the affected area; use enough to completely cover the wound, a layer about 1/6 of an inch thick Apply dressing in a closed room with low circulation of air to help prevent contamination First apply the cream to the gauze, then cut the dressing to the proper size for the wound; be sure to use either a disposable instrument or a sterilized instrument When applied to fresh wounds, it is normal for the gauze to turn a brown color from the cream How it Works Scientists do not yet completely understand how Silver Sulfadiazine works. However, they do know it provides antimicrobial activity that is broad in nature. It can effectively combat Staph and E. coli strains of bacteria. It can be used in the prevention of infection where burns have penetrated skin. It can also bring relief to itching associated with the healing process. Special Precautions Never use this medication for animals allergic to sulfite drugs or this medication. In lactating or pregnant females, use with caution. Overdose Information Immediately contact your closest emergency animal hospital or vet. Side Effects Silver Sulfadiazine's possible side effects include: Itching Burning Pain Other less frequently occurring events include: Interstitial nephritis Rash Burning sensation Skin discoloration Erythema multiforme Skin necrosis Storage Store in a cool, dry place. Do not freeze. Tips To prevent anything from getting into the cream or the wound, apply dressing in a closed room with low circulation of air. Apply the cream to the gauze and cut dressing to proper size for the wound. Either use a disposable instrument or sterilize it before using. Use enough cream to cover the wound, approximately 1/6 of an inch thick. When applied to fresh wounds, it is normal for the gauze to turn a brown color from the cream. Directions Use as directed by a veterinarian.