Effaclar Adapalene Gel 0.1% Retinoid Acne Treatment from La Roche-Posay is an FDA-approved prescription-strength retinoid acne treatment. This oil-free, fragrance-free acne treatment contains adapalene gel, a dermatologist recommended retinoid. Retinoids, such as adapalene, are vitamin A derivatives that regulate skin cell turnover to help clear skin and prevent blackheads, whiteheads, clogged pores, and acne blemishes. Key Ingredients: Adapalene: a prescription-strength retinoid that regulates skin cell turnover to prevent clogged pores and treat acne Key Benefits: Helps clear blackheads, whiteheads, clogged pores, and acne blemishes Prevents new acne from forming Oil-free and non-comedogenic; fragrance-free Tip: The American Academy of Dermatology (AAD) describes topical retinoids as a treatment of choice for mild, moderate and severe acne. Adapalene 0.1% is FDA approved to be safe and effective for over-the-counter use.