SAMe participates in many critical metabolic functions by donating methyl groups to other molecules. Methyl groups need to be transferred between compounds in the body to help with things like neurotransmitter signaling and protein function. Laboratory research has shown that SAMe levels appear to decline over time.SAMe is a compound that has been studied by numerous scientists, researchers and even the U.S. government.SAMe Benefits Helps maintain stable mood Promotes liver health Supports healthy joint function