About Low Dose Naltrexone Immune Modulation Anti-Inflammatory Effects Mental health benefits How it Works Low Dose Naltrexone (LDN) operates by binding to and temporarily blocking opioid receptors, a mechanism typically associated with higher doses of the medication. At lower doses, approximately ranging from 1 to 5 mg, LDN is believed to stimulate the production of endorphins, the body's natural opioids. This unique modulation of endorphin levels contributes to its potential in immune modulation, anti-inflammatory effects, and influencing cellular processes for overall well-being.