About Enclomiphene In Men, Enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone. How it Works Enclomiphene, a selective estrogen receptor modulator (SERM), operates by binding to estrogen receptors in the hypothalamus, a region of the brain that plays a crucial role in regulating hormonal balance. By doing so, enclomiphene blocks the negative feedback effects of estrogen, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This heightened GnRH production subsequently stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), ultimately leading to the stimulation of testosterone production in men.