Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) is the broadest* parasite protection of its kind covering 6 types of parasites in one chewable tablet. It protects against ticks, fleas, heartworm disease and the three intestinal worms that can be passed to humans — tapeworms, roundworms and hookworms†. Credelio Quattro is effective and works fast where it counts. It kills over 99% of fleas within 8 hours of administration and remains effective for an entire month. What's more, Credelio Quattro contains lotilaner that kills ticks** twice as fast†† as sarolaner in Simparica Trio and afoxolaner in NexGard†††. This FDA-approved medication delivers all the protection your dog needs in a convenient monthly chewable. It uses four powerful ingredients to provide the broadest* protection that lasts all month long by covering 6 types of parasites. Credelio Quattro comes in a tasty, easy-to-give chewable that's also meat allergy friendly***. In fact, Credelio Quattro was accepted by nearly 9 out of 10 dogs.*Based on label comparison of the number of parasite types covered in a chewable that covers ticks**Amblyomma americanum (lone star tick)***Elanco Animal Health. Data on file. †Uncinaria stenocephala ††Based on the time to statistical significance vs. control in a study on Day 21 and Day 28 for reinfestations. The study compared Credelio (lotilaner)—not Credelio Quattro, which contains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the active ingredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and NexGard (afoxolaner). ††† Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG, Bell MC, Beltz MS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR, Sutherland CJ. Comparative speed of kill provided by lotilaner (Credelio), sarolaner(Simparica Trio), and afoxolaner (NexGard) to control Amblyomma americanum infestations on dogs. Parasit Vectors. 2024 Jul 20;17(1):313."