Simparica Trio Chewable Tablets for Dogs Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs. This simple-to-give oral monthly treatment protects dogs against heartworm disease as well as against ticks and fleas and intestinal worms like roundworms and hookworms. It can eliminate as many as five tick species: gulf coast ticks, American dog ticks, Lone star ticks, deer ticks, and Brown dog ticks. Simparica Trio kills fleas before they can lay eggs and begins to kill existing fleas within 4 hours. Moreover, this treatment is approved for puppies and dogs over the age of 8 weeks old. How Does It Work? Simparica Trio is made up of three ingredients – Sarolaner, Moxidectin, and Pyrantel. Sarolaner helps in the thorough elimination of fleas and ticks whereas Moxidectin aids in the prevention of heartworm disease. On the other hand, Pyrantel helps in treating and controlling roundworms and hookworms. Note: We recommend consulting your vet before buying this product. Pets with a history of seizure attacks should only be treated with this product after consulting a vet.