Pairing L-methylfolate with a B-complex vitamin is a nutritional power move for mood and energy support. B-Complex vitamins, including B6, and B12, complement L-methylfolate's benefits by supporting energy metabolism and neurotransmitter production. They also support the adrenals for healthy stress response. Adequate levels of all B vitamins are necessary for sustained energy. B vitamins play a role in metabolizing food energy and healthy oxygen levels in the circulation, both of which can help combat fatigue and promote vitality.