Heat Disclaimer:  Suppositories are shipped on Mondays through Wednesdays and require expedited shipping. It is important to retrieve the package promptly after delivery to avoid exposure to heat and warm temperatures. International shipping is not available. Xeneplex suppositories are made with natural espresso and reduced glutathione, which aid the body in dealing with harmful substances such as pesticides, petrochemicals, plasticizers, solvents, metals, artificial flavors, synthetic colors, mold, and fungal aflatoxins. Xeneplex offers the benefits of a coffee enema and a glutathione I.V. in a suppository form, making it ideal for individuals who suffer from chemical sensitivities. While glutathione can assist the body in managing metals and other chemicals, we recommend combining it with EDTA for better results. This way, EDTA can help the body in dealing with toxic metals, while glutathione can focus on supporting the body in managing chemical issues. Shipping Notice: ⚠️ This item is temperature sensitive and must remain refrigerated to preserve potency.🚚 Overnight shipping with cold pack handling is required.📦 Not eligible for free domestic ground shipping. **If you chose a cheaper ground method for shipping, we cannot guarantee the effectiveness of this product and cannot honor a refund on melted suppositories.