The Feathered Serpent or Quetzalcóatl was one of the most praised gods in ancient Mesoamerica. Commonly represented as a serpent, each Mesoamerican region identified Quetzalcóatl with “aspects” in which he was associated with various gods. Mesoamerica’s history and culture has helped us build a better understanding on how psychedelic plants influenced ancient societies and religion. Many pre-Columbian Mesoamerican cultures used hallucinogenic cactus, plants and mushrooms for medicinal and religious purposes.