Experience microneedling in a bottle. This advanced-strength Microcrystal Activated PM Serum 5000 is powered by spicules—microscopic, needle-like particles derived from hydrolyzed sea sponge—that penetrate the skin’s surface and create microchannels, allowing active ingredients to reach deeper layers of the skin and work more effectively. The 5000 Strength Serum enhances ingredient absorption by +342%*, boosts collagen production, and treats acne at the source. Azelaic Acid-coated spicules accelerate cell renewal, while Copper Peptide improves elasticity and hydration. Cica PDRN treatment promotes skin repair and helps fade acne scars. Designed with shorter spicules for deeper delivery and less irritation, this liquid microneedling formula is ideal for experienced users dealing with deep-rooted skin concerns like fine lines and texture. If this advanced strength serum is too strong, consider of our other products like our 2000 strength formula instead. *Based on 20 participants, ages 20-59 after 1 use in a clinical study