Nutramax Denamarin for Large Dogs combines the power of S-adenosylmethionine (SAMe) and silybin to help support healthy liver function in dogs. Administering SAMe may help increase liver levels of glutathione, an important antioxidant for liver health. While best known for supporting the liver in cats and dogs, the SAMe in Denamarin may also help support cognitive function. Denamarin includes silybin, a bioactive component of milk thistle extract, and works to support liver function by helping support a healthy oxidative balance. Denamarin is brought to you by Nutramax Laboratories Veterinary Sciences, Inc. Nutramax has been a leader in pet health for over 30 years, and provides supplements to support joint health, digestive health, skin and coat health, calming, and more.